Esthélis™ Dermal Filler

Are you looking to iron out wrinkles around the eyes and across the forehead get rid of creases on and around the lips, boost lip volume, fill in nasolabial folds and clear away glabellar lines, smooth out scars and other depressions in the skin then Esthélis™ may be the answer for you!

Less product, more superficial injection, achieving less side effects and long lasting results - that is Esthélis™ in a nutshell.

Esthélis™ is a hyaluronic acid based injectable filler that comes in a smooth highly cross-linked gel form to restore or increase the volume of skin tissue. 

It is commended for its ability to achieve natural and long lasting results from a smaller amount of product that is injected more superficially into the skin. 


The unique formula of this dermal filler infiltrates and integrates in the skin's layers, allowing for immediate results that look as good shortly following treatment as they do months afterward. 


And because of its makeup, ergonomic syringe and specialized injection technique, there are less negative side effects related to treatment.

Esthélis™ is manufactured by Anteis, a Swiss company specializing in injectable medical devices.

For more information about Esthélis™ and how dermal fillers could work for you visit mdmedical.com

Who can be treated with Esthélis™?

Esthélis™ is designed for men and women who want to increase volume in the skin to treat wrinkles, creases, furrows, folds and depressions. It can also redefine the contours of the lips.

Who should not use Esthélis™?

Pregnant or breastfeeding women should not be treated. If the targeted area is inflamed or infected, treatment may be rescheduled.

What should I do to prepare for treatment?

The injection area should be clean, healthy and free of infection or inflammation.

How long is a session?

The average length of treatment is half an hour.

Does it hurt?

This depends on you. A topical anesthetic may be applied prior to injection to alleviate discomfort.

What can I expect after treatment?

You should see immediate results. Redness and swelling may occur however they are considered temporary and should disappear within a few hours or days.

What should I do to help recovery?

Avoiding touching the treated area after injection for a couple of days. Do not apply makeup, perform strenuous physical activity, or expose the area to severe temperature fluctuations. Cover the area from sun exposure. A complete list of post treatment instruction will be given to you. Follow them closely to facilitate the healing process.

How long do results last?

In general, it is recommended that a maintenance treatment is scheduled after about 9-12 months for Esthelis and Fortelis. Modelis can last 1.5 to 2 years.

photos courtesy of Anteis

MODELIS SHAPE: CONTOURING FILLER

NEW PRODUCT: Modelis Shape

Modelis Shape is a new volume dermal filler based on Anteis technology of polydensification pushed to the extreme, called Hybrid Plastic Matrix technology. 


This technology make it possible to treat in a very natural way volumes of the face, offers a higher biocompatibility (no migration) and a product that last for 2 years. 


Very malleable and with a higher plasticty, Modelis is clearly shown to make of the 'Shaping' for the face, i.e. which it is able to reorganize entirely, mainly in areas requiring large volumes of fillers like the knobs or the cheeks, for example.

Modelis has just been introduced on the Canadian market. Modelis allows:

• To reorganize/reshape the face (cheeks, oval of the face, chin, nose, jawline)

• To carve the reliefs of the face

• To change the proportions of the face

• To restore the volumes lost on the level of the facial depressions related on the age or the disease (Modelis can be employed to correct the effects of the reduction in the facial lubricating mass (lipoatrophie) at the people carrying virus HIV)

Modelis was conceived with the double objective to offer an extraordinary capacity of modeling and to make the injection comfortable. The technology HPM developed by Anteis is the only one to offer this specific combination. Thanks to this technology, associating the properties of elasticity, cohesivity and plasticity, Modelis has the following advantages:

Strong volumetric capacity ,Great ease of injection

• Absence of migration of the product

• Remarkable Malleability and Plasticty

• Correction of long life ( 2 to 2,5 years)

• Perfect and sure Bio-compatibility

CANNULA INJECTIONS

  NEW TECHNIQUE: cannula injections.

Blunt Cannulas are the most advanced technique for injecting dermal fillers. They are the injection tool of choice in Europe and are growing in use in North America. Cannulas are flexible blunt 'needles' with a side hole for product extrusion. 


Since these cannulas are not sharp, they do not cut vessels so there is no bruising. Instead of cutting through the tissue like a needle, cannulas push tissue out of the way. Cannulas do not cut any nerve, muscle so very little discomfort is felt during or after procedures. We have succeeded to place dermal fillers even in the lips without the need of numbing. However, local anesthesia is offered if requested. With only 2-3 entry points, we can place the dermal filler anywhere is needed.

MESOLIS: REHYDRATING MESO THERAPY

The most recent product from this range (Mesolis), offers a rehydrating mesotherapy based on glycerol and hyaluronic acid. 


Mesotherapy is done very superficially, with little down-time. This rejuvenating gel has unique properties in retaining water based on naturally occurring components of the human body.

There are no risks for any allergic reactions.

Mesolis and Mesolis+ Excellent results in chronic eczema.

Mesotherapy for Skin Tightening/Rejuvenation, Lipolysis, Alopecia Skin tightening / Rejuvenation and Cellulite Reduction- SR+ SR+ combines 56 of the most effective ingredients for facial rejuvenation, combining Cytokines, Coenzymes, Vitamins, Minerals, Anti-Oxidants, Amino Acids, and Natural Moisture Factors, making it the most complete skin care treatment available. SR+ targets the underlying factors that cause aging, while also treating the skin at the surface, restoring its natural youthful look. This total approach to healthier looking skin has brought SR+ to the forefront of the fight against premature aging. Cytokines SR+ uses a breakthrough advance in anti aging referred to as Cytokine Technology. Cytokines are proteins manufactured by cells that when released, drive specific functions in other cells. This advanced treatment focuses specifically on chosen cytokines to act as intercellular mediators that increase the cellular interchange necessary for maintaining healthy looking skin. Coenzymes Coenzymes are often used to stimulate cellular reactions. In SR+ specific coenzymes are used to restore energy to skin cells in a natural way. As anti-oxidants they help repair dry and aged skin, nourish the deeper layers of skin, and provide energy to the cells of the epidermis. When used for skin care, Coenzymes will: • Moisturize • Increase Skin Translucency • Combat fine lines • Reduce puffiness • Brighten skin Vitamines, Minerals, Antioxidants SR+ combines vitamins A through E, known for their rejuvenating action on the skin, along with other restorative minerals and antioxidants to create a synergistic anti aging effect on the skin. This breakthrough combination of vitamins and antioxidants helps stimulate new collagen production, reducing the appearance of aging, while also providing protection against aging factors and environmental damage. This two step approach treats the skin both inside and out. Below the surface the vitamins act to rebuild damaged collagen, allowing you to exfoliate dead skin, and reveal the more youthful skin that has replaced it. On the surface the minerals and antioxidants nourish and moisturize the new skin, while also making it more resilient to aging factors and environmental damage, such as UVA and UVB rays. The result is more youthful looking skin. AminoAcids Amino Acids have in recent years been increasingly developed and researched, showing promising results for the skin care market. Their entry into the anti-aging and skin care industry has brought with it the introduction of new and emerging amino acids that provide numerous benefits to aging skin. The amino acids used in SR+ consist of Neuropeptides and Pentapeptides, which are small proteins characterized by their effectiveness and safety in minute doses when used by the body. Neuropeptides are especially known for their powerful ability to affect cell interaction and to increase the quality of cell communication. In SR+ the amino acids go to work to make skin appear smoother, in addition to improving skin tone and colour, reducing fine lines and minimizing the appearance of sun damage. Natural Moisture Factor All of the ingredients in SR+ were specifically chosen for their secondary moisturizing effects on the skin, but one ingredient in particular, Hyaluronic Acid, was chosen for its excellent water retention factor. Hyaluronic acid can hold nearly one thousand times its weight in water. It is naturally occurring in the body, and keeps the skin moisturized. It was recently recognized by the FDA for its amazing moisturizing qualities, and is used to make SR+ one of the most hydrating skin care treatments available. Lypoless Lypoless� is the newest product on the market using �mesotherapy� ingredients to burn fat and provide a tighter skin tone. As a pre mixed cocktail, Lypoless� combines the leading and most powerful ingredients known to metabolize fat deposits and tone the skin in one easy to use treatment. Phosphatidylcholine Phosphatidylcholine is a substance that is known to break down fat and was initially used to treat the build up of plaque in heart disease, but has recently been discovered to be a safe, effective and low cost treatment for localized fat deposits. Phosphatidylcholine is a phospholipid extracted from soybean lecithin or egg shells, and is found in abundance in cell membranes, where its role is to participate in the structure and transport between cells. The cosmetic use of phosphatidylcholine originated in the late 1980�s in Italy, and was perfected in Brazil about a decade later, where studies have been conducted showing evidence of its efficacy in treating localized fat under the eyes, on the thighs, hips, abdomen, and neck.Though not yet fully understood, the action of phosphatidylcholine injected into subcutaneous tissue is said to penetrate the adipose tissue through the phospholipid bi-layer, acting as an emulsifying agent. The physical and chemical characteristics of the fat deposit would then be altered, making it water soluble. The body is then said to eliminate this foreign substance. L-Carnithine L-carnitine in an amino acid that causes fat oxidation. It works by carrying fat to the mitochondrial inner membrane where it is used to produce energy. Without L-carnitine, the normal burning of fat cannot take place, but when injected directly into fatty deposits L-Carnitine causes a dramatic increase in the rate of fat metabolism, and also facilitates the metabolism of carbohydrates and enhances the rate of cellular respiration. L-Carnitine works synergistically with phosphatidylcholine to enhance its effects. Hyaluronic Acid Hyaluronic acid production occurs in the deep dermis. Scientists have speculated that the reason behind its proven ability to helps keep skin smooth is its excellent water retention capabilities. In recent studies they have also found that hyaluonic acid helps repair wounds and other skin problems. Hyaluronic acid is also responisble for maintaining the body�s collagen levels. Collagen depletion in the body is considered by scientists to be one of the leading causes of poor skin tone and elasticity, greatly contributing to the visual aging process. Hyaluronic acid was recently recognized by the FDA for its amazing anti-aging and moisturizing qualities. As we age, the hyaluronic acid in our bodies decreases, causing our skin to endure the signs of aging. The hyaluronic acid in Lypoless� is aimed at tightening and smoothing the skin, and will help reverse the signs of aging. IGF Insulin-Like Growth Factor 1 is a growth factor closely resembling insulin. After growth hormone is secreted by the pituitary gland it is then taken to the liver where it is used to produce IGF-1. The IGF-1 is then used by the body to ensure that muscle mass is lean, and that fatty tissue is not stored. It also helps reduce fat that is already present. IGF-1 and hyaluronic acid work together to keep your skin tight, and help maintain leaner, younger looking skin.The combination of these four fat burning components creates one of the most powerful tools to help you achieve your desired body image. Phosphatidylcholine and L-Carnitine, long known for their syngergistic lypolytic effect, combined with Hyaluronic Acid and IGF-1, the most recent breakthroughs in cosmetic rejuvenation, come together to form a product unparalleled in the treatment of localized fat. HL / Alopecia treatment solution Although the cause of hair loss is not yet fully understood, there are many underlying factors that are shown to be associated with the loss of function of our hair follicles as we age. HL is aimed at treating the known factors in order to stop the progress of hair loss and stimulate the re-growth of new hair. Like SR+, HL uses Cytokines, Coenzymes, Vitamins, Minerals and AminoAcids to provide a localized increase in blood flow to nourish and rejuvenate the cells. What makes HL unique , however, are the three main components that are directly related to the treatment of hair loss: Gluthatione, an antioxidant well known for its ability to stimulate cell growth, as well as two key growth factors used in the production of hair: Fibroblast Growth factor and Vascular Endothelial Growth factor. Mesotherapy - skin rejuvenation/ skin tightening after 7 treatments (7 weeks)

ANTHEIS INJECTION SYSTEM

NEW DEVICE: Inject Pen, The Anteis Injection System

 The Anteis Injection System, an automated delivery system for all glass syringe fillers. 


The system has several advantages:

A significant reduction in pain during and after injection, thanks to the improved regulation of flow. Physicians can choose between three delivery speeds, a small, medium or larger volume and bolus or flow, allowing you to concentrate on placement instead of injection force. It works with both needle and cannulas. 

The AIS offers patients a reduction in side effects and a faster return to everyday life.

Patients who have tried this new system find they have less bruising, pain, redness and swelling, and can therefore return to work or social activities without anyone realizing that they have had a treatment. The system is also of great value in Mesotherapy, as offers a precise and constant volume injection. 


Anteis Injection Pen is set to become the new industry standard. The AIS system is available through MD Medical in Montreal, Canada. www.mdmedical.ca

ESTHELIS: THE NEXT GENERATION OF DERMAL FILLERS

  Swiss Made Dermal Fillers ( Modelis Shape, Fortelis Extra, Esthelis Basic and Soft, Mesolis)

Esthelis, Fortelis and Modelis are new and unique double-cross linked hyaluronic acid, of non-animal origin, made in Switzerland by Anteis (anteis.com), and used in Europe since 2003. It is available in Canada through mdmedical.com.


Anteis has brought to market the next generation of dermal resorbable fillers for face and body sculpturing:

• modeling - correcting deep folds, facial contours and reliefs(cheeks) , increasing lip volume, lifting eyebrow, jawline
• filling - smoothing wrinkles and lines, nasolabial folds, enhancing lips, filling tear troughs, smiling lines, correcting scars
• smoothing - correcting all type of wrinkle,lip contours and volume, marionettes line,periorbital lines
• hydrating - rejuvenation source even for the most dehydrated skin, restoring the skin's elasticity and glow; preventing the appearance of wrinkles and cracks.

These are perfectly homogenous products, with a better dermal bio-integration for the most natural results, with no lumps or bumps.It gives you more volume and they are more natural.See attached a comparison with other dermal fillers, published recently:

One of the key properties of the product compared to other competitors on the market is that it can be injected very superficially (Esthelis soft), treating thus the smallest wrinkles of your skin.

Another great advantage is that the products last for about 1 year, more than several other resorbable fillers ( for Fortelis and E.basic) and up to 2 years for Modelis Shape.

Ideally, dermal fillers should be performed 20 days after Botox treatment and as part of a complete combination treatment, which includes: botulinum toxin, skin laser treatment and than hyaluronic acid (fillers). Deep injections can be done anytime, as they are not reachable by the laser used for skin rejuvenation.

No downtime for this procedure, treatment takes 30-45 min when local anesthesia is needed.

  

  

ESTHÉLIS - DETAILED SCIENTIFIC INFORMATION

1. Monophasic polydensified is the future

No granulomas and no cordon effects… for perfect and completely natural results                                                          

To fully understand the reasons why look at the following photos:

Biphasic gel

Do you see the particles? Biphasic products are heterogeneous and remain so, even during injections causing side effects such as  irregularities and cordons in the skin.

   

Monophasic monodensified gel

Can you see the uneven surface of this implant? Despite its monophasic nature its texture still shows some irregularities due to the single level of cross-linking. This causes side effects such as cordons and lumps in the skin.

   

Monophasic polydensified – Esthélis

Are you able to appreciate the perfectly smooth surface block of Esthélis? Its  nature and cohesive  polydensified matrix makes it completely homogeneous causing no side effects.

   

Better volume maintenance…

In the following animation, when you click on it, you can observe the different bio-degradation effects using biphasic products, monophasic monofensified and Esthélis (monophasic and polydensified) products. Imagine the consequences for skin tissue volumes and wrinkle-filling!

… and equally perfect long-term results

Esthélis offers very satisfactory long-term results with the average maintenance periods being approximately 9 months and in many cases even exceeding 12 months.

Comparative study on comparing Esthélis and another similar gel 

Anteis carried out a comparative study between Esthélis and a biphasic gel. The images below show that, at day 21, on the same person injected with a different product in each naso-labial furrow, Esthélis offers clearly more convincing results in the short term regarding the filling effectiveness.

Biphasic
Monophasic                                      Polydensified-CPM: Esthélis


Biphasic
Monophasic                                      Polydensified-CPM: Esthélis


The last two pictures are taken after 240 days and prove that Esthélis provides a visible filling result over the long term.

2. Monophasic polydensified is the future
…and CPM is the leading-edge technology of the future

The true technological advances of Esthélis are the result of the unique patented manufacturing process: 

The CPM technology (Cohesive Polydensified Matrix).

CPM technology is based on a dynamic cross-linking process which takes place in five key stages.


Stage 1

Pure hyaluronic acid


Stage 2

Linearization of the hyaluronic acid


Stage 3

First, classical, cross-linking of H.A. by adding BDDE

These first three stages are the same as those currently used 

in the cross-linking process of any hyaluronic acid products.

Stage 4

Drawing the first cross-linked level


Stage 5

Second cross-linking, unique for Anteis, with the further addition of H.A. and followed by terminal purification.

To see the CPM Technology animation, click here

These additional two key stages are the innovative part of CPM Technology, patented 

by Anteis®, using a dynamic cross-linking process.

What is the result of this dynamic cross-linking process?

Two different density levels in a single product that is, however, monophasic, with:

• Denser parts (more tightly cross-linked) that are designed to provide long-lasting results
• Less dense parts (less tightly cross-linked) for gels that are easier to inject and  handle
• A capacity to integrate into different zone of the dermis, without conceding any loss of volume or the long lastingness of the results. 

Esthélis is the only range of monophasic fillers containing a Cohesive and Polydensified Matrix.